The purpose of the present investigation was to formulate and evaluate matrix tablets of valsartan sodium using different polymers and study the release of drug depending on the concentration of the polymer. The polymers used for the present investigation were xanthum gum, carbopol 934, HPMC K100M. The tablets were prepared by direct compression method. The drug polymer interaction was investigated by FTIR and their results directed further course of formulation. Valsartan tablets were evaluated for various post compression parameters like tablet hardness, friability, weight variation, drug content and in-vitro dissolution. The results were found to be within the acceptable limits. The time required for 90% (t90%) drug dissolution was selected as dependent variable. The formulations F1, F4, F7 showed that the drug release was concentration dependent and followed first order kinetics. While the formulations F2, F3, F6, F8 and F9 showed that drug release followed zero order kinetics. Formulation F9 was selected as an optimized one where the drug release sustained for a period of 12 hrs. Kinetic treatment to the in-vitro release data revealed that the drug release followed zero order non–fickian diffusion with n value greater than 0.45.
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